Contact information
Research groups
Colleges
Fabian Grabenhorst
DPhil
Associate Professor of Experimental Psychology
- Wellcome Trust Sir Henry Dale Fellow
- Fellow and Tutor in Experimental Psychology at Jesus College
Neural mechanisms of reward, economic decisions, and social behaviour
My work focuses on the brain's reward system, and how this system contributes to economic decision-making and social behaviour. Why do we like foods high in sugar and fat, and sometimes struggle to control their intake? How do our decisions and thoughts about our social partners emerge from neural activity patterns in particular brain structures?
To address these questions, my group uses single-neuron recordings and neuroimaging to investigate the activity of neural reward structures in controlled behavioural experiments. By studying their functions in reward, decisions, and social behaviour, we aim to better understand how these brain systems can dysfunction in human diseases.
Our recent work identified nutrients and sensory food qualities, including a food’s viscosity and sliding friction, as key reward properties that shape economic food preferences. We now study how neurons in the amygdala—a major structure of the brain’s reward system—assign values to these reward components and process them into decisions.
In a separate approach, we found that neurons in the amygdala learn to predict the choices of social partners by spontaneously simulating a partner’s decision processes.
Key publications
Preferences for fat, sugar, and oral-sensory food qualities in monkeys and humans.
Journal article
Huang F-Y. and Grabenhorst F., (2025), Physiol Behav, 299
Dynamic coding and sequential integration of multiple reward attributes by primate amygdala neurons.
Journal article
Grabenhorst F. and Báez-Mendoza R., (2025), Nat Commun, 16
Social Risk Coding by Amygdala Activity and Connectivity with the Dorsal Anterior Cingulate Cortex.
Journal article
Kim J-C. et al, (2025), J Neurosci, 45
The amygdala and the pursuit of future rewards.
Journal article
Johnson ST. and Grabenhorst F., (2024), Front Neurosci, 18
view-based decision mechanism for rewards in the primate amygdala.
Journal article
Grabenhorst F. et al, (2023), Neuron, 111, 3871 - 3884.e14
Neural Mechanism in the Human Orbitofrontal Cortex for Preferring High-Fat Foods Based on Oral Texture.
Journal article
Khorisantono PA. et al, (2023), J Neurosci, 43, 8000 - 8017
Nutrient-Sensitive Reinforcement Learning in Monkeys.
Journal article
Huang F-Y. and Grabenhorst F., (2023), J Neurosci, 43, 1714 - 1730
Functions of primate amygdala neurons in economic decisions and social decision simulation.
Journal article
Grabenhorst F. and Schultz W., (2021), Behav Brain Res, 409
Preferences for nutrients and sensory food qualities identify biological sources of economic values in monkeys.
Journal article
Huang F-Y. et al, (2021), Proc Natl Acad Sci U S A, 118
Neural Mechanisms for Accepting and Rejecting Artificial Social Partners in the Uncanny Valley.
Journal article
Rosenthal-von der Pütten AM. et al, (2019), J Neurosci, 39, 6555 - 6570
Primate prefrontal neurons signal economic risk derived from the statistics of recent reward experience.
Journal article
Grabenhorst F. et al, (2019), Elife, 8
Primate Amygdala Neurons Simulate Decision Processes of Social Partners.
Journal article
Grabenhorst F. et al, (2019), Cell, 177, 986 - 998.e15
Primate amygdala neurons evaluate the progress of self-defined economic choice sequences.
Journal article
Grabenhorst F. et al, (2016), Elife, 5
dynamic code for economic object valuation in prefrontal cortex neurons.
Journal article
Tsutsui K-I. et al, (2016), Nat Commun, 7
Planning activity for internally generated reward goals in monkey amygdala neurons.
Journal article
Hernádi I. et al, (2015), Nat Neurosci, 18, 461 - 469
Prediction of economic choice by primate amygdala neurons.
Journal article
Grabenhorst F. et al, (2012), Proc Natl Acad Sci U S A, 109, 18950 - 18955
Value, pleasure and choice in the ventral prefrontal cortex.
Journal article
Grabenhorst F. and Rolls ET., (2011), Trends Cogn Sci, 15, 56 - 67
How the brain represents the reward value of fat in the mouth.
Journal article
Grabenhorst F. et al, (2010), Cereb Cortex, 20, 1082 - 1091
How pleasant and unpleasant stimuli combine in different brain regions: odor mixtures.
Journal article
Grabenhorst F. et al, (2007), J Neurosci, 27, 13532 - 13540
Recent publications
Value coding by primate amygdala neurons complies with the continuity axiom of economic choice theory.
Journal article
Grabenhorst F. et al, (2026), J Neurophysiol
Preferences for fat, sugar, and oral-sensory food qualities in monkeys and humans.
Journal article
Huang F-Y. and Grabenhorst F., (2025), Physiol Behav, 299
Dynamic coding and sequential integration of multiple reward attributes by primate amygdala neurons.
Journal article
Grabenhorst F. and Báez-Mendoza R., (2025), Nat Commun, 16
Social Risk Coding by Amygdala Activity and Connectivity with the Dorsal Anterior Cingulate Cortex.
Journal article
Kim J-C. et al, (2025), J Neurosci, 45
The amygdala and the pursuit of future rewards.
Journal article
Johnson ST. and Grabenhorst F., (2024), Front Neurosci, 18
view-based decision mechanism for rewards in the primate amygdala.
Journal article
Grabenhorst F. et al, (2023), Neuron, 111, 3871 - 3884.e14
Neural Mechanism in the Human Orbitofrontal Cortex for Preferring High-Fat Foods Based on Oral Texture.
Journal article
Khorisantono PA. et al, (2023), J Neurosci, 43, 8000 - 8017
Correction to: Mechanisms of adjustments to different types of uncertainty in the reward environment across mice and monkeys.
Journal article
Woo JH. et al, (2023), Cogn Affect Behav Neurosci, 23
Mechanisms of adjustments to different types of uncertainty in the reward environment across mice and monkeys.
Journal article
Woo JH. et al, (2023), Cogn Affect Behav Neurosci, 23, 600 - 619
Nutrient-Sensitive Reinforcement Learning in Monkeys.
Journal article
Huang F-Y. and Grabenhorst F., (2023), J Neurosci, 43, 1714 - 1730
NUTRIENTS AND FOOD TEXTURES: INFLUENCES ON PREFERENCES, LEARNING, AND NEURAL REWARD PROCESSING IN PRIMATES SYMPOSIUM: ACQUISITION AND MODIFICATION OF FLAVOR PREFERENCES.
Conference paper
Grabenhorst F., (2023), CHEMICAL SENSES, 48
Functions of primate amygdala neurons in economic decisions and social decision simulation.
Journal article
Grabenhorst F. and Schultz W., (2021), Behav Brain Res, 409
Preferences for nutrients and sensory food qualities identify biological sources of economic values in monkeys.
Journal article
Huang F-Y. et al, (2021), Proc Natl Acad Sci U S A, 118
Nonhuman Primates Satisfy Utility Maximization in Compliance with the Continuity Axiom of Expected Utility Theory.
Journal article
Ferrari-Toniolo S. et al, (2021), J Neurosci, 41, 2964 - 2979
Experimentally revealed stochastic preferences for multicomponent choice options.
Journal article
Pastor-Bernier A. et al, (2020), J Exp Psychol Anim Learn Cogn, 46, 367 - 384
Non-human primates satisfy utility maximization in compliance with the continuity axiom of Expected Utility Theory
Preprint
Ferrari-Toniolo S. et al, (2020)
Neural Mechanisms for Accepting and Rejecting Artificial Social Partners in the Uncanny Valley.
Journal article
Rosenthal-von der Pütten AM. et al, (2019), J Neurosci, 39, 6555 - 6570
Primate prefrontal neurons signal economic risk derived from the statistics of recent reward experience.
Journal article
Grabenhorst F. et al, (2019), Elife, 8
Primate Amygdala Neurons Simulate Decision Processes of Social Partners.
Journal article
Grabenhorst F. et al, (2019), Cell, 177, 986 - 998.e15
Neural Basis for Economic Saving Strategies in Human Amygdala-Prefrontal Reward Circuits.
Journal article
Zangemeister L. et al, (2016), Curr Biol, 26, 3004 - 3013
Primate amygdala neurons evaluate the progress of self-defined economic choice sequences.
Journal article
Grabenhorst F. et al, (2016), Elife, 5
dynamic code for economic object valuation in prefrontal cortex neurons.
Journal article
Tsutsui K-I. et al, (2016), Nat Commun, 7
Planning activity for internally generated reward goals in monkey amygdala neurons.
Journal article
Hernádi I. et al, (2015), Nat Neurosci, 18, 461 - 469
The representation of oral fat texture in the human somatosensory cortex.
Journal article
Grabenhorst F. and Rolls ET., (2014), Hum Brain Mapp, 35, 2521 - 2530
ention-dependent modulation of cortical taste circuits revealed by Granger causality with signal-dependent noise.
Journal article
Luo Q. et al, (2013), PLoS Comput Biol, 9
Food labels promote healthy choices by a decision bias in the amygdala.
Journal article
Grabenhorst F. et al, (2013), Neuroimage, 74, 152 - 163
Prediction of economic choice by primate amygdala neurons.
Journal article
Grabenhorst F. et al, (2012), Proc Natl Acad Sci U S A, 109, 18950 - 18955
Componential Granger causality, and its application to identifying the source and mechanisms of the top-down biased activation that controls attention to affective vs sensory processing.
Journal article
Ge T. et al, (2012), Neuroimage, 59, 1846 - 1858
edonically complex odor mixture produces an attentional capture effect in the brain.
Journal article
Grabenhorst F. et al, (2011), Neuroimage, 55, 832 - 843
Value, pleasure and choice in the ventral prefrontal cortex.
Journal article
Grabenhorst F. and Rolls ET., (2011), Trends Cogn Sci, 15, 56 - 67
Choice, difficulty, and confidence in the brain.
Journal article
Rolls ET. et al, (2010), Neuroimage, 53, 694 - 706
Decision-making, errors, and confidence in the brain.
Journal article
Rolls ET. et al, (2010), J Neurophysiol, 104, 2359 - 2374
entional modulation of affective versus sensory processing: functional connectivity and a top-down biased activation theory of selective attention.
Journal article
Grabenhorst F. and Rolls ET., (2010), J Neurophysiol, 104, 1649 - 1660
common neural scale for the subjective pleasantness of different primary rewards.
Journal article
Grabenhorst F. et al, (2010), Neuroimage, 51, 1265 - 1274
How the brain represents the reward value of fat in the mouth.
Journal article
Grabenhorst F. et al, (2010), Cereb Cortex, 20, 1082 - 1091
Neural systems underlying decisions about affective odors.
Journal article
Rolls ET. et al, (2010), J Cogn Neurosci, 22, 1069 - 1082
Different representations of relative and absolute subjective value in the human brain.
Journal article
Grabenhorst F. and Rolls ET., (2009), Neuroimage, 48, 258 - 268
Prediction of subjective affective state from brain activations.
Journal article
Rolls ET. et al, (2009), J Neurophysiol, 101, 1294 - 1308
From affective value to decision-making in the prefrontal cortex.
Journal article
Grabenhorst F. et al, (2008), Eur J Neurosci, 28, 1930 - 1939
The orbitofrontal cortex and beyond: from affect to decision-making.
Journal article
Rolls ET. and Grabenhorst F., (2008), Prog Neurobiol, 86, 216 - 244
Selective attention to affective value alters how the brain processes olfactory stimuli.
Journal article
Rolls ET. et al, (2008), J Cogn Neurosci, 20, 1815 - 1826
Warm pleasant feelings in the brain.
Journal article
Rolls ET. et al, (2008), Neuroimage, 41, 1504 - 1513
How cognition modulates affective responses to taste and flavor: top-down influences on the orbitofrontal and pregenual cingulate cortices.
Journal article
Grabenhorst F. et al, (2008), Cereb Cortex, 18, 1549 - 1559
Selective attention to affective value alters how the brain processes taste stimuli.
Journal article
Grabenhorst F. and Rolls ET., (2008), Eur J Neurosci, 27, 723 - 729
Human cortical representation of oral temperature.
Journal article
Guest S. et al, (2007), Physiol Behav, 92, 975 - 984
How pleasant and unpleasant stimuli combine in different brain regions: odor mixtures.
Journal article
Grabenhorst F. et al, (2007), J Neurosci, 27, 13532 - 13540
Role of the amygdala in decisions under ambiguity and decisions under risk: evidence from patients with Urbach-Wiethe disease.
Journal article
Brand M. et al, (2007), Neuropsychologia, 45, 1305 - 1317
Elevated emotional reactivity in affective but not cognitive components of theory of mind: a psychophysiological study.
Journal article
Kalbe E. et al, (2007), J Neuropsychol, 1, 27 - 38
Decisions under ambiguity and decisions under risk: correlations with executive functions and comparisons of two different gambling tasks with implicit and explicit rules.
Journal article
Brand M. et al, (2007), J Clin Exp Neuropsychol, 29, 86 - 99
How pleasant and unpleasant stimuli combine in the brain: The neural representation of odor mixtures
Conference paper
Grabenhorst F. et al, (2007), NERVENARZT, 78, 249 - 250