Research groups
Louise Isham
MA MSc DClinPsy DPhil
Research Clinical Psychologist
I am a research clinical psychologist within O-CAP. The overall aim of my research is to improve psychological treatments for people experiencing severe mental health problems, with a particular focus on developing the psychological understanding and treatment of harmful grandiose delusions. I have worked as a trial therapist on several of the O-CAP trials including the Feeling Safe Study - a clinical trial investigating a novel psychological intervention for persecutory beliefs, and the OWLS trial - a pilot randomised controlled trial of a sleep intervention designed specifically for psychiatric inpatients.
In addition to my role within O-CAP I also work as a consultant clinical psychologist for the Oxford Cognitive Therapy Centre, which provides specialist CBT training and supervision. My area of specialism is CBT for psychosis and I am the course lead for the OCTC/University of Oxford PGCert in Enhanced CBT: Psychosis and Bipolar. I am an HCPC registered Clinical Psychologist and BABCP accredited CBT practitioner.
Recent publications
Learning How to Improve the Treatment of Persecutory Delusions: Using a Principal Trajectories Analysis to Examine Differential Effects of Two Psychological Interventions (Feeling Safe, Befriending) in Distinct Groups of Patients.
Journal article
Jenner L. et al, (2026), Schizophr Bull, 52
Ten misconceptions about CBT for psychosis
Journal article
Newman-Taylor K. et al, (2025), Cognitive Behaviour Therapist, 18
CBT for psychosis with a young adult experiencing grandiose beliefs: a case study
Journal article
Brown P. et al, (2025), Cognitive Behaviour Therapist, 18
A 6-month supported online program for the treatment of persecutory delusions: Feeling Safer.
Journal article
Freeman D. et al, (2025), Psychol Med, 55
Efficacy of a 6-month supported online programme (Feeling Safer) for the treatment of persecutory delusions: protocol for a randomised controlled trial.
Journal article
Freeman D. et al, (2025), BMJ Open, 15
Prior Expectations of Volatility Following Psychotherapy for Delusions: A Randomized Clinical Trial.
Journal article
Sheffield JM. et al, (2025), JAMA Netw Open, 8