Napier S., Wishart G., Arbuckle W., Baker J., Barn D., Bingham M., Brown A., Byford A., Claxton C., Craighead M., Buchanan K., Fielding L., Gibson L., Goodwin R., Goutcher S., Irving N., MacSweeney C., Milne R., Mort C., Presland J., Sloan H., Thomson F., Turnbull Z., Young T.

The discovery of a novel series of 8-azabicyclo[3.2.1]octan-3-yl)-3-(4-chlorophenyl) propanamide antagonists of the vasopressin V(1A) receptor is disclosed. Compounds 47 and 48 were found to be high affinity, selective vasopressin V(1A) antagonists.

The discovery of novel 8-azabicyclo[3.2.1]octan-3-yl)-3-(4-chlorophenyl) propanamides as vasopressin V1A receptor antagonists.

Napier S., Wishart G., Arbuckle W., Baker J., Barn D., Bingham M., Brown A., Byford A., Claxton C., Craighead M., Buchanan K., Fielding L., Gibson L., Goodwin R., Goutcher S., Irving N., MacSweeney C., Milne R., Mort C., Presland J., Sloan H., Thomson F., Turnbull Z., Young T.

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