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Genetic mouse models relevant to schizophrenia complement, and have to a large extent supplanted, pharmacological and lesion-based rat models. The main attraction is that they potentially have greater construct validity; however, they share the fundamental limitations of all animal models of psychiatric disorder, and must also be viewed in the context of the uncertain and complex genetic architecture of psychosis. Some of the key issues, including the choice of gene to target, the manner of its manipulation, gene-gene and gene-environment interactions, and phenotypic characterization, are briefly considered in this commentary, illustrated by the relevant papers reported in this special issue.

Original publication

DOI

10.1016/j.neuropharm.2011.08.009

Type

Journal article

Journal

Neuropharmacology

Publication Date

03/2012

Volume

62

Pages

1164 - 1167

Keywords

Animals, Disease Models, Animal, Gene-Environment Interaction, Genetic Predisposition to Disease, Humans, Mice, Schizophrenia