Sex-specific disease modifiers in juvenile myoclonic epilepsy.
Shakeshaft A., Panjwani N., Collingwood A., Crudgington H., Hall A., Andrade DM., Beier CP., Fong CY., Gardella E., Gesche J., Greenberg DA., Hamandi K., Koht J., Lim KS., Møller RS., Ng CC., Orsini A., Rees MI., Rubboli G., Selmer KK., Striano P., Syvertsen M., Thomas RH., Zarubova J., Richardson MP., Strug LJ., Pal DK.
Juvenile myoclonic epilepsy (JME) is a common idiopathic generalised epilepsy with variable seizure prognosis and sex differences in disease presentation. Here, we investigate the combined epidemiology of sex, seizure types and precipitants, and their influence on prognosis in JME, through cross-sectional data collected by The Biology of Juvenile Myoclonic Epilepsy (BIOJUME) consortium. 765 individuals met strict inclusion criteria for JME (female:male, 1.8:1). 59% of females and 50% of males reported triggered seizures, and in females only, this was associated with experiencing absence seizures (OR = 2.0, p