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OBJECTIVE: This study tested the hypothesis that degeneration of the corticofugal tracts (CFTs) is related to poor functional outcome in the upper limb after stroke. METHODS: . The authors used diffusion tensor imaging to determine the degree of white matter integrity of the CFT (FA(AH/UH)) in chronic stroke patients and controls. The functional integrity of the corticospinal pathway was examined using transcranial magnetic stimulation. Recruitment curves and silent period duration were measured. The relationship between FA(AH/UH) and functional outcome of the upper limb was also assessed using a battery of upper limb function tests. RESULTS: In patients, FA( AH/UH) correlated positively with the slope of recruitment curves (RC(AH/UH)) and grip strength. FA(AH/UH) also correlated negatively with the silent period duration (SP(AH/UH)). According to the FA(AH/UH), patients were also classified into groups with minimal or extensive Wallerian degeneration (WD). Patients with more extensive WD had poorer grip strength, dexterity, and range of movement. CONCLUSIONS: The authors' results suggest that structural and functional integrity of the CFT is essential to maintain function of the upper limb after stroke.

Original publication




Journal article


Neurorehabil Neural Repair

Publication Date





551 - 560


Adult, Aged, Chronic Disease, Diffusion Magnetic Resonance Imaging, Female, Hand, Humans, Male, Middle Aged, Pilot Projects, Predictive Value of Tests, Pyramidal Tracts, Recovery of Function, Stroke, Transcranial Magnetic Stimulation, Wallerian Degeneration