Cookies on this website
We use cookies to ensure that we give you the best experience on our website. If you click 'Continue' we'll assume that you are happy to receive all cookies and you won't see this message again. Click 'Find out more' for information on how to change your cookie settings.

The actions of benzodiazepines were studied on the responses to GABA of the fast coxal depressor (D(f)) motor neurone of the cockroach, Periplaneta americana. Ro5-4864, diazepam and clonazepam were investigated. Responses to GABA receptors were enhanced by both Ro5-4864 and diazepam, whereas clonazepam, a potent-positive allosteric modulator of human GABA(A) receptors, was ineffective on the native insect GABA receptors of the D(f) motor neurone. Thus, clear pharmacological differences exist between insect and mammalian native GABA-gated chloride channels with respect to the actions of benzodiazepines. The results enhance our understanding of invertebrate GABA-gated chloride channels which have recently proved important in (a) comparative studies aimed at identifying human allosteric drug-binding sites and (b) understanding the actions of compounds used to control ectoparasites and insect crop pests.

Original publication




Journal article


Invert Neurosci

Publication Date





85 - 89


Animals, Benzodiazepines, Benzodiazepinones, Chloride Channels, Clonazepam, Diazepam, Dose-Response Relationship, Drug, Evoked Potentials, GABA Modulators, Glutamic Acid, In Vitro Techniques, Insect Proteins, Male, Membrane Potentials, Microelectrodes, Motor Neurons, Periplaneta, gamma-Aminobutyric Acid