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We describe two rare cases of alien limb syndrome following right posterior cerebral artery (PCA) stroke. Both patients present with left hemianopia, visual neglect and proprioceptive loss in addition to their alien limb symptoms. Lesion subtraction from seven control PCA patients revealed that medial parietal-occipital and thalamic areas were selectively damaged in the alien limb patients. We propose that loss of the sense of motor intention and internal model of the current state of the arm, combined with deficient proprioceptive and visual feedback of the moving limb, are critical for genesis of posterior alien limb and discuss how affected regions normally function to ensure awareness of self-generated motor activity.

Original publication

DOI

10.1002/mds.21546

Type

Journal article

Journal

Mov Disord

Publication Date

30/07/2007

Volume

22

Pages

1498 - 1502

Keywords

Aged, Cerebral Arterial Diseases, Extremities, Female, Hemianopsia, Humans, Magnetic Resonance Imaging, Cine, Male, Memory Disorders, Middle Aged, Movement, Neurologic Examination, Neuropsychological Tests, Stroke, Syndrome