Recent studies using transgenic mice lacking NMDA receptors in the hippocampus challenge the long-standing hypothesis that hippocampal long-term potentiation-like mechanisms underlie the encoding and storage of associative long-term spatial memories. However, it may not be the synaptic plasticity-dependent memory hypothesis that is wrong; instead, it may be the role of the hippocampus that needs to be re-examined. We present an account of hippocampal function that explains its role in both memory and anxiety.
Nat Rev Neurosci
181 - 192
Animals, Anxiety, Behavior, Animal, Hippocampus, Memory, Mice, Mice, Knockout, Neuronal Plasticity, Receptors, N-Methyl-D-Aspartate, Space Perception, Synapses, Synaptic Transmission