Cookies on this website
We use cookies to ensure that we give you the best experience on our website. If you click 'Continue' we'll assume that you are happy to receive all cookies and you won't see this message again. Click 'Find out more' for information on how to change your cookie settings.

Accumulating evidence has shown that a polymorphism in the promoter region of the serotonin-transporter (5-HTTLPR) modulates neural activation during the perceptual processing of emotional facial expressions. Furthermore, behavioral research has shown that attentional bias for negative information is increased in s allele carriers. We examined the interactions among 5-HTTLPR (including SNP rs25531), life events and gender on the detection of facial emotions. We found a main effect of genotype, as well as moderating effects of childhood emotional abuse (CEA) and recent life events (RLE). S homozygous participants recognized negative facial expressions at a lower intensity than the other genotype groups. This effect was more evident in female participants and in participants who had experienced life events. The 5-HTTLPR genotype affects facial emotional perception, a process which is linked to a neurobiological response to threat and vulnerability to emotional disorders.

Original publication

DOI

10.1016/j.neuroscience.2010.10.042

Type

Journal article

Journal

Neuroscience

Publication Date

13/01/2011

Volume

172

Pages

303 - 313

Keywords

Adolescent, Adult, Adult Survivors of Child Abuse, Emotions, Female, Genetic Predisposition to Disease, Genotype, Humans, Male, Middle Aged, Mood Disorders, Perceptual Disorders, Serotonin Plasma Membrane Transport Proteins, Sex Characteristics, Sex Factors, Stress, Psychological, Young Adult