By investigating the topology of neuronal co-activity, we found that mnemonic information spans multiple operational axes in the mouse hippocampus network. High-activity principal cells form the core of each memory along a first axis, segregating spatial contexts and novelty. Low-activity cells join co-activity motifs across behavioral events and enable their crosstalk along two other axes. This reveals an organizational principle for continuous integration and interaction of hippocampal memories.
Journal article
2021-03-01T00:00:00+00:00
24
326 - 330
4
Action Potentials, Animals, Conditioning, Operant, Hippocampus, Memory, Mice, Nerve Net, Neurons, Sucrose