Thalamus, Cortex & Cognition
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Funded by Wellcome Trust and Royal Society and MRC
Prof. Anna S Mitchell
How do subcortical and cortical brain structures interact to support complex cognition?
We focus on how different subdivisions of the dorsal thalamus interact with the frontal lobes and cingulate/retrosplenial cortex to support our ability to learn new information, remember and make decisions.
Our group focuses on how our brain works when we learn new information, navigate and make adaptive, rapid decisions. Our particular interest is with the dorsal thalamus and its interactions with cortex (thalamo-cortical networks and transthalamic loops). We use behavioural and cognitive neuroscience methods to understand how the medial thalamus and interconnected cortical regions contribute to learning new information, remembering, navigation and decision-making as well as other cognitive processes (e.g. planning).
One of our focuses is on the mediodorsal thalamus (it is the largest subdivision of the medial thalamus) and its interactions with the prefrontal cortex. The functions of the mediodorsal thalamus are still not yet well defined and its role in many neurological disorders and psychiatric diseases remains speculative.
We have recently provided the first causal evidence of the importance of interactions between the mediodorsal thalamus and prefrontal cortex during learning complex information on a trial-by-trial basis and adaptive decision-making in primates (Browning, Chakraborty, Mitchell, 2015, Cerebral Cortex).
Other recent findings show the critical role of the mediodorsal thalamus in updating reward-guided learning in uncertain or changing environments (Chakraborty, Kolling, Walton, Mitchell, 2016, eLife). We also have further causal behavioural evidence to demonstrate that the integrity of the mediodorsal thalamus is critical in supporting the prefrontal cortex during tasks involving cognitive flexibility, including documenting neuroimaging changes after damage to the mediodorsal thalamus.
Our other main focus concerns interactions between the retrosplenial cortex and the anterior thalamic nuclei (also located within the medial thalamus) with our recent publication demonstrating the critical role for the retrosplenial cortex in supporting our ability to retain previously acquired information (Buckley and Mitchell, 2016, Cerebral Cortex).
We use a multidisciplinary approach to advancing fundamental knowledge about the interactions between nuclei of the medial thalamus and their cortical targets during performing cognitive processes. We combine cognitive and behavioural neuroscience techniques including electrophysiology, neuroimaging, neurocognitive testing, disruption to selective brain targets in animals, neuroanatomy, immunohistochemistry and immuno-electron microscopy. We also assess cognitive and behavioural changes in patients with medial thalamic strokes using neuropsychological testing and neuroimaging.
Some of our work is conducted in humans, while other studies involve us investigating our hypotheses using animal models (rodents and non-human primates). You can explore our non-human primate lab via a virtual tour here http://www.labanimaltour.org/ . For this work, we were awarded the 2017 Understanding Animals in Research Public Engagement Award.
I have also recently contributed to the discussion about the importance of animal research including primate research in neuroscience, its importance for advancing our fundamental understanding about brain functions that in some cases can support the discovery of ways to treat serious conditions, and the ways in which animal welfare is safeguarded. http://metro.co.uk/2018/03/20/why-are-primates-still-used-in-uk-experiments-7367751/
Finally, I explain why I use non-human primates in my research via an interview with the Wellcome Trust here https://www.facebook.com/wellcometrust/videos/608674132916002
- Dr Subhojit Chakraborty – Postdoctoral Researcher