By investigating the topology of neuronal co-activity, we found that mnemonic information spans multiple operational axes in the mouse hippocampus network. High-activity principal cells form the core of each memory along a first axis, segregating spatial contexts and novelty. Low-activity cells join co-activity motifs across behavioral events and enable their crosstalk along two other axes. This reveals an organizational principle for continuous integration and interaction of hippocampal memories.
Journal article
Nat Neurosci
03/2021
24
326 - 330
Action Potentials, Animals, Conditioning, Operant, Hippocampus, Memory, Mice, Nerve Net, Neurons, Sucrose