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Deletion of the GluA1 AMPA receptor subunit selectively impairs short-term memory for spatial locations. We further investigated this deficit by examining memory for discrete nonspatial visual stimuli in an operant chamber. Unconditioned suppression of magazine responding to visual stimuli was measured in wild-type and GluA1 knockout mice. Wild-type mice showed less suppression to a stimulus that had been presented recently than to a stimulus that had not. GluA1 knockout mice, however, showed greater suppression to a recent stimulus than to a nonrecent stimulus. Thus, GluA1 is not necessary for encoding, but affects the way that short-term memory is expressed.

Original publication

DOI

10.1101/lm.2014911

Type

Journal article

Journal

Learn Mem

Publication Date

03/2011

Volume

18

Pages

128 - 131

Keywords

Analysis of Variance, Animals, Behavior, Animal, Conditioning, Classical, Female, Male, Memory Disorders, Memory, Short-Term, Mice, Mice, Knockout, Photic Stimulation, Receptors, AMPA, Time Factors