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Recent studies using transgenic mice lacking NMDA receptors in the hippocampus challenge the long-standing hypothesis that hippocampal long-term potentiation-like mechanisms underlie the encoding and storage of associative long-term spatial memories. However, it may not be the synaptic plasticity-dependent memory hypothesis that is wrong; instead, it may be the role of the hippocampus that needs to be re-examined. We present an account of hippocampal function that explains its role in both memory and anxiety.

Original publication

DOI

10.1038/nrn3677

Type

Journal article

Journal

Nat Rev Neurosci

Publication Date

03/2014

Volume

15

Pages

181 - 192

Keywords

Animals, Anxiety, Behavior, Animal, Hippocampus, Memory, Mice, Mice, Knockout, Neuronal Plasticity, Receptors, N-Methyl-D-Aspartate, Space Perception, Synapses, Synaptic Transmission