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It is widely held that dopamine signaling encodes predictions of future rewards and such predictions are regularly used to drive behavior, but the relationship between these two is poorly defined. We found in rats that nucleus accumbens dopamine following a reward-predicting cue was attenuated unless movement was correctly initiated. Our results indicate that dopamine release in this region is contingent on correct action initiation and not just reward prediction.

Original publication

DOI

10.1038/nn.4187

Type

Journal article

Journal

Nat Neurosci

Publication Date

01/2016

Volume

19

Pages

34 - 36

Keywords

Animals, Behavior, Animal, Cues, Dopamine, Male, Motor Activity, Nucleus Accumbens, Rats, Rats, Sprague-Dawley, Reward, Signal Transduction