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We have developed an integrated microfabricated cell sorter using multilayer soft lithography. This integrated cell sorter is incorporated with various microfluidic functionalities, including peristaltic pumps, dampers, switch valves, and input and output wells, to perform cell sorting in a coordinated and automated fashion. The active volume of an actuated valve on this integrated cell sorter can be as small as 1 pL, and the volume of optical interrogation is approximately 100 fL. Different algorithms of cell manipulation, including cell trapping, were implemented in these devices. We have also demonstrated sorting and recovery of Escherichia coli cells on the chip.

Original publication

DOI

10.1021/ac0255330

Type

Journal article

Journal

Anal Chem

Publication Date

01/06/2002

Volume

74

Pages

2451 - 2457

Keywords

Bacteriological Techniques, Escherichia coli, Nanotechnology