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Diffusion tensor imaging (DTI), a magnetic resonance imaging technique, is used to infer major axonal projections in the macaque and human brain. This study investigates the feasibility of using known macaque anatomical connectivity as a "gold-standard" for the evaluation of DTI tractography methods. Connectivity information is determined from the DTI data using fast marching tractography (FMT), a novel tract-tracing (tractography) method. We show for the first time that it is possible to determine, in an entirely noninvasive manner, anatomical connection pathways and maps of an anatomical connectivity metric in the macaque brain using a standard clinical scanner and that these pathways are consistent with known anatomy. Analogous human anatomical connectivity is also presented for the first time using the FMT method, and the results are compared. The current limitations of the methodology and possibilities available for further studies are discussed.

Original publication




Journal article



Publication Date





797 - 809


Animals, Axons, Brain Mapping, Cerebral Cortex, Diffusion, Female, Image Enhancement, Image Processing, Computer-Assisted, Imaging, Three-Dimensional, Macaca fascicularis, Magnetic Resonance Imaging, Mesencephalon, Neural Pathways, Species Specificity, Ultrasonography