Cookies on this website

We use cookies to ensure that we give you the best experience on our website. If you click 'Accept all cookies' we'll assume that you are happy to receive all cookies and you won't see this message again. If you click 'Reject all non-essential cookies' only necessary cookies providing core functionality such as security, network management, and accessibility will be enabled. Click 'Find out more' for information on how to change your cookie settings.

Prof. Mark Walton

We are interested in the way in which our brains are able to integrate across these multiple different types of information in order to guide appropriate decisions.  There is a particular focus on how different aspects of value are learned, represented and used to guide choice behaviour within frontal-striatal-dopaminergic circuits.  The long-term goal is to use the information gleaned about the function of these systems to better understand how the process of valuation and decision making goes awry in neuropsychiatric disorders.

The laboratory uses a range of recording and interference techniques to address these questions, including fibre photometry, fast-scan cyclic voltammetry, optogenetics and neuropharmacological manipulations.  In particular, we are keen to use combinations of techniques in order to probe communication between brain regions and causal interactions within these networks.  Our behavioural tasks are designed with an eye to ideas in disciplines such as behavioural ecology, animal learning theory and neuroeconomics as well as behavioural and cognitive neuroscience.

See lab website for more details

 

 

 

 

 

Our team

Key publications

Dopamine-independent effect of rewards on choices through hidden-state inference.

Journal article

Blanco-Pozo M. et al, (2024), Nat Neurosci, 27, 286 - 297

Nucleus accumbens D1-receptors regulate and focus transitions to reward-seeking action.

Journal article

Grima LL. et al, (2022), Neuropsychopharmacology, 47, 1721 - 1731

Distinct roles for dopamine clearance mechanisms in regulating behavioral flexibility.

Journal article

Korn C. et al, (2021), Mol Psychiatry, 26, 7188 - 7199

Mesolimbic Dopamine Encodes Prediction Errors in a State-Dependent Manner.

Journal article

Papageorgiou GK. et al, (2016), Cell Rep, 15, 221 - 228

ction initiation shapes mesolimbic dopamine encoding of future rewards.

Journal article

Syed ECJ. et al, (2016), Nat Neurosci, 19, 34 - 36

Dissociable cost and benefit encoding of future rewards by mesolimbic dopamine.

Journal article

Gan JO. et al, (2010), Nat Neurosci, 13, 25 - 27

Related research themes