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- Brain and Behaviour Research Group (Prof. Mark J. Buckley) Research Group
Professor of Behavioural and Cognitive Neuroscience
- Fellow of The Queen's College
I head the Brain and Behaviour Research Group in which we conduct basic neuroscience research to determine how neural systems underlie behaviour and cognition. Applied research aimed at relieving debilitating brain disease and disorders (e.g. dementias, amnesias, Schizophrenia, mood disorders etc.) depends crucially on basic research advancing understanding of how normal neural activity underlies normal behaviour, in addition to understanding why abnormal and dysfunctional behaviour may occur when these brain networks are compromised. For example, we have long been interested in understanding how brain areas in the temporal lobes and in associated regions, some of which become dysfunction in dementias including Alzheimer’s Disease, operate in mediating perception and memory. Likewise we have also focused our attention on understanding how more anterior brain regions in the frontal lobes operate in mediating learning and memory as well as other key elements of cognition including choice behaviour and goal-directed behaviour. An overarching theme of the current research in my laboratory is to progress beyond the traditional focus of research on individual regions and move to an understanding of how networks of interconnected brain regions interact together to mediate normal learning, memory and cognition. To do this we have to investigate both normal and abnormal brain function using a range of complementary neuropsychological, neurophysiological, and neuroimaging techniques. Our work is funded by the MRC and Wellcome Trust.
Essential functions of primate frontopolar cortex in cognition.
Boschin EA. et al, (2015), Proc Natl Acad Sci U S A, 112, E1020 - E1027
Dissociable components of rule-guided behavior depend on distinct medial and prefrontal regions.
Buckley MJ. et al, (2009), Science, 325, 52 - 58
Mnemonic function of the dorsolateral prefrontal cortex in conflict-induced behavioral adjustment.
Mansouri FA. et al, (2007), Science, 318, 987 - 990
A role for the macaque anterior cingulate gyrus in social valuation.
Rudebeck PH. et al, (2006), Science, 313, 1310 - 1312
Conflict-induced behavioural adjustment: a clue to the executive functions of the prefrontal cortex.
Mansouri FA. et al, (2009), Nat Rev Neurosci, 10, 141 - 152
Transcranial magnetic stimulation to dorsolateral prefrontal cortex affects conflict-induced behavioural adaptation in a Wisconsin Card Sorting Test analogue.
Boschin EA. et al, (2017), Neuropsychologia, 94, 36 - 43
Monitoring Demands for Executive Control: Shared Functions between Human and Nonhuman Primates.
Mansouri FA. et al, (2017), Trends Neurosci, 40, 15 - 27
Distinct Roles for the Anterior Cingulate and Dorsolateral Prefrontal Cortices During Conflict Between Abstract Rules.
Boschin EA. et al, (2017), Cereb Cortex, 27, 34 - 45
A Putative Multiple-Demand System in the Macaque Brain.
Mitchell DJ. et al, (2016), J Neurosci, 36, 8574 - 8585
Retrosplenial Cortical Contributions to Anterograde and Retrograde Memory in the Monkey.
Buckley MJ. and Mitchell AS., (2016), Cereb Cortex, 26, 2905 - 2918
Adaptability to changes in temporal structure is fornix-dependent.
Kwok SC. et al, (2015), Learn Mem, 22, 354 - 359
Behavioral consequences of selective damage to frontal pole and posterior cingulate cortices.
Mansouri FA. et al, (2015), Proc Natl Acad Sci U S A, 112, E3940 - E3949