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I will describe a range of results from neuroscientific investigation of approximately 700 healthy individuals from 18-88 years of age in the CamCAN project (www.cam-can.org), including: 1) separation of the effects of age on vascular vs neural components of the BOLD response by combining resting-state fMRI and MEG; 2) mediation by white matter (measured from diffusion kurtosis imaging) of effect of age on latency of evoked MEG responses, 3) state-dependent effects of age on fMRI connectivity across rest, sensorimotor task and movie-watching; 4) (de)differentiation of white-matter and cognition with age using multi-group structural equation modelling, 5) functional compensation in prefrontal cortex using multivariate decoding and 6) evidence of a unique contribution of mid-life activities to cognitive reserve in old age (using plain old multiple regression).

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