Ageing, Brain and Cognition: Results from the Cambridge Centre for Ageing & Neuroscience (CamCAN)
Professor Rik Henson (Cambridge)
Wednesday, 22 November 2017, 1pm to 2pm
Wellcome Centre for Intergrative Neuroimaging, Oxford Centre for Functional MRI of the Brain (FMRIB), John Radcliffe Hospital, Oxford, OX3 9DU
I will describe a range of results from neuroscientific investigation of approximately 700 healthy individuals from 18-88 years of age in the CamCAN project (www.cam-can.org), including: 1) separation of the effects of age on vascular vs neural components of the BOLD response by combining resting-state fMRI and MEG; 2) mediation by white matter (measured from diffusion kurtosis imaging) of effect of age on latency of evoked MEG responses, 3) state-dependent effects of age on fMRI connectivity across rest, sensorimotor task and movie-watching; 4) (de)differentiation of white-matter and cognition with age using multi-group structural equation modelling, 5) functional compensation in prefrontal cortex using multivariate decoding and 6) evidence of a unique contribution of mid-life activities to cognitive reserve in old age (using plain old multiple regression).