Departmental Seminar: Transdiagnostic mapping in neurodevelopmental disorders
Dr Duncan Astle, University of Cambridge
Departmental Seminar Series
Thursday, 27 May 2021, 12.15pm to 1.15pm
Hosted by Professor Gaia Scerif
Macroscopic brain organisation emerges early in life, even prenatally, and continues through adolescence and into early adulthood. The emergence and continual refinement of large-scale brain networks, connecting neuronal populations across anatomical distance, allows for increasing functional integration and specialisation. This process is thought crucial for the emergence of complex cognitive processes. But how and why is this process so diverse?
We used structural neuroimaging collected from 479 children (299 boys, ranging in age from 62 to 223 months) who are members of an intentionally diverse cohort of struggling learners to explore how different features of macroscopic brain organisation are associated with diverse cognitive trajectories. We used diffusion-weighted imaging (DWI) to construct whole-brain white-matter connectomes. A simulated attack on each child's connectome revealed that some brain networks were strongly organised around highly connected ‘hubs’. The more children’s brains were critically dependent on hubs, the better their cognitive skills. Conversely, having poorly integrated hubs was a very strong risk factor for cognitive and learning difficulties across the sample.
We subsequently developed a computational framework, using generative network modelling (GNM), to model the emergence of this kind of connectome organisation. Relatively subtle changes within the wiring rules of this computational framework give rise to differential developmental trajectories, because of small biases in the preferential wiring properties of different nodes within the network. Finally, we were able to use this GNM to identify the molecular and cellular processes that govern these different growth patterns. To our knowledge this provides the application of this kind of computational framework to explore diversity human brain development.
About the speaker
Dr Duncan Astle is a Programme Leader at the MRC Cognition and Brain Sciences Unit, University of Cambridge.
His 4D Research Group captures a broad programme of developmental cognitive neuroscience. A hallmark of this science has been methodological innovations for understanding neural systems in childhood, how they are linked with developmental disorder, and how they respond to intervention.
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