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Rats with complete cytotoxic hippocampal lesions exhibited spatial memory impairments in both the water maze and elevated T maze. They were hyperactive in photocell cages; swam faster in the water maze; and were less efficient on a nonspatial, differential reinforcement of low rates (DRL) task. Performance on both spatial tasks was also impaired by selective dorsal but not ventral lesions; swim speed was increased by ventral but not dorsal lesions. Both partial lesions caused a comparable reduction in DRL efficiency, although these effects were smaller than those of complete lesions. Neither partial lesion induced hyperactivity when rats were tested in photocell cages, although both complete and ventral lesion groups showed increased activity after footshock in other studies (Richmond et al., 1999). These results demonstrate possible functional dissociations along the septotemporal axis of the hippocampus.

Type

Journal article

Journal

Behav Neurosci

Publication Date

12/1999

Volume

113

Pages

1170 - 1188

Keywords

Analysis of Variance, Animals, Excitatory Amino Acid Antagonists, Hippocampus, Hyperkinesis, Locomotion, Male, Maze Learning, Microinjections, N-Methylaspartate, Rats, Rats, Inbred Strains, Space Perception