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GluA1 AMPA receptor subunit knockout mice display a selective impairment on short-term recognition memory tasks. In this study we tested whether GluA1 is important for short-term memory that is necessary for bridging the discontiguity between cues in trace conditioning. GluA1 knockout mice were not impaired at using short-term memory traces of T-maze floor inserts, made of different materials, to bridge the temporal gap between conditioned stimuli and reinforcement during appetitive discrimination tasks. Thus, different aspects of short-term memory are differentially sensitive to GluA1 deletion. This dissociation may reflect processing of qualitatively different short-term memory traces. Memory that results in performance of short-term recognition (e.g. for objects or places) may be different from the memory required for associative learning in trace conditioning.

Original publication




Journal article


Behav Brain Res

Publication Date





8 - 14


Animals, Association Learning, Conditioning (Psychology), Cues, Discrimination (Psychology), Disease Models, Animal, Female, Maze Learning, Memory Disorders, Memory, Short-Term, Mice, Mice, Knockout, Receptors, AMPA, Space Perception