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Patients with damage to the prefrontal cortex (PFC)--especially the ventral and medial parts of PFC--often show a marked inability to make choices that meet their needs and goals. These decision-making impairments often reflect both a deficit in learning concerning the consequences of a choice, as well as deficits in the ability to adapt future choices based on experienced value of the current choice. Thus, areas of PFC must support some value computations that are necessary for optimal choice. However, recent frameworks of decision making have highlighted that optimal and adaptive decision making does not simply rest on a single computation, but a number of different value computations may be necessary. Using this framework as a guide, we summarize evidence from both lesion studies and single-neuron physiology for the representation of different value computations across PFC areas.

Original publication

DOI

10.1037/a0023575

Type

Journal article

Journal

Behav Neurosci

Publication Date

06/2011

Volume

125

Pages

297 - 317

Keywords

Animals, Brain Mapping, Choice Behavior, Cognition, Decision Making, Frontal Lobe, Learning, Neurons, Prefrontal Cortex, Reward