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Despite widespread interest in neural mechanisms of decision-making, most investigations focus on decisions between just two options. Here we adapt a biophysically plausible model of decision-making to predict how a key decision variable, the value difference signal-encoding how much better one choice is than another-changes with the value of a third, but unavailable, alternative. The model predicts a surprising failure of optimal decision-making: greater difficulty choosing between two options in the presence of a third very poor, as opposed to very good, alternative. Both investigation of human decision-making and functional magnetic resonance imaging-based measurements of value difference signals in ventromedial prefrontal cortex (vmPFC) bore out this prediction. The vmPFC signal decreased in the presence of low-value third alternatives, and vmPFC effect sizes predicted individual variation in suboptimal decision-making in the presence of multiple alternatives. The effect contrasts with that of divisive normalization in parietal cortex.

Original publication

DOI

10.1038/nn.3649

Type

Journal article

Journal

Nat Neurosci

Publication Date

03/2014

Volume

17

Pages

463 - 470

Keywords

Adult, Attention, Decision Making, Female, Functional Neuroimaging, Humans, Magnetic Resonance Imaging, Male, Neural Networks (Computer), Prefrontal Cortex, Psychomotor Performance, Young Adult