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In a double-blind, placebo-controlled trial comparing alprazolam and imipramine for panic disorder, serum analysis revealed that a substantial proportion of the patients took explicitly prohibited anxiolytic medication. Excluding these patients changed the results.

Original publication

DOI

10.1176/ajp.147.4.507

Type

Journal article

Journal

Am J Psychiatry

Publication Date

04/1990

Volume

147

Pages

507 - 509

Keywords

Adult, Alprazolam, Anti-Anxiety Agents, Anxiety Disorders, Clinical Trials as Topic, Double-Blind Method, Fear, Female, Humans, Imipramine, Male, Outcome and Process Assessment (Health Care), Panic, Patient Compliance, Placebos, Self Medication