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Mammalian brains exhibit population oscillations, the structures of which vary in time and space according to behavioural state. A proposed function of these oscillations is to control the flow of signals among anatomically connected networks. However, the nature of neural coding that may support selective communication that depends on oscillations has received relatively little attention. Here, we consider the role of multiplexing, whereby multiple information streams share a common neural substrate. We suggest that multiplexing implemented through periodic modulation of firing-rate population codes enables flexible reconfiguration of effective connectivity among brain areas.

Original publication




Journal article


Nat Rev Neurosci

Publication Date





111 - 122


Action Potentials, Animals, Biological Clocks, Brain, Humans, Mammals, Models, Neurological, Nerve Net, Neural Pathways, Neurons, Time Factors